Few Christian denominations can claim the antiquity of the Syriac Orthodox Church of Antioch, whose foundations can be traced back to the very dawn of Christianity. The Church justifiably prides itself as being one of the earliest established apostolic churches. It was in Antioch, after all, that the followers of Jesus were called Christians as we are told in the New Testament, "The disciples were first called Christians in Antioch." (Acts 11:26).

According to ecclesiastical tradition, the Church of Antioch is the second established church in Christendom after Jerusalem, and the prominence of its Apostolic See is well documented. In his Chronicon (I, 2), the church historian Eusebius of Caesarea tells us that Apostle St. Peter established a bishopric in Antioch and became its first bishop. He also tells us that St. Peter was succeeded by Evodius. In another historical work, Historia Ecclesiastica, Eusebius tells us that Ignatius the Illuminator, "a name of note to most men, [was] the second after Peter to the bishopric of Antioch" (III, 36).